The hairless nature of this breed can predispose to exposure to solar radiation and sunburn. Repeated sunburns can cause skin cancers, such as squamous cell carcinoma, which are like nasty ulcerated sores that never heal and slowly get bigger. Squamous cell carcinomas become infected and can bleed and cause discomfort. Actinic dermatitis can also develop from chronic ultraviolet radiation and skin changes that block hair follicles. Large draining breasts can develop that ooze material that collects deep into the skin.

The Chinese crested dog breed also suffers from atopic dermatitis. many of these dogs are affected. Atopic dermatitis tends to appear on hairless parts of the body. In a breed covered with normal hair, atopic dermatitis manifests itself on the feet, groin, armpit or armpit, abdomen, and the concave or inner surface of the ears. Until recently, the understanding of canine atopic dermatitis was that allergens were inhaled. This key fact remains true, but it is only part of the story. A recent advance was the discovery that dogs with canine atopic dermatitis have a defective skin barrier. The skin barrier is deficient in a protein called sphingosine. The absence of sphingosine causes the skin to leak. Moisture escapes from the skin causing it to dry out. Allergens pass through the skin and trigger an immune reaction that manifests as an itchy rash.

Therefore, the Hairless Chinese Crested Dog has large body parts that are not protected by hair. In Chinese crested dogs with canine atopic dermatitis, the irritating itchy rash can envelop almost the entire body.

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